Hydrochloric Acid → N-(2-ethoxycarbonyloxy-4-methoxybenzoyl)cysteamine

HRID 465916

반응식

HRID 465916 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:12])[C:6](=[CH:10][CH:11]=1)[C:7]([OH:9])=O.[C:13](Cl)(=[O:17])[O:14][CH2:15][CH3:16].[NH2:19][CH2:20][CH2:21][SH:22].Cl>C(Cl)Cl.C(N(CC)CC)C>[CH2:15]([O:14][C:13]([O:12][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([NH:19][CH2:20][CH2:21][SH:22])=[O:9])=[O:17])[CH3:16]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6058CysteamineHCID 10928Ethyl chloroformateHCID 752314-Methoxysalicylic Acid

생성물 1

HCID 14719509N-(2-ethoxycarbonyloxy-4-methoxybenzoyl)cysteamine수율 89%

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8471Triethylamine용매

반응 조건

온도
-15 °C

실험 절차

Under argon atmosphere, 2.84 g of 4-methoxysalicylic acid was dispersed in 45 ml of methylene chloride, and the dispersion was cooled to -15° C. To the dispersion was added 3.76 g of triethylamine and 3.77 g of ethyl chlorocarbonate, and the mixture was agitated for 1.5 hour. To the mixture was added a solution of 1.56 g of cysteamine in 5 ml of methylene chloride, and the mixture was agitated at -15° C. for 2 hours. The reaction mixture was poured into 1N aqueous hydrochloric acid, and extracted with methylene chloride. The organic layer was washed with saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. The solvent was distilled off in evacuated atomosphere, and the residue was subjected to column chromatography using silica gel. There was obtained 4.50 g of N-(2-ethoxycarbonyloxy-4-methoxybenzoyl)cysteamine.

후처리

  1. stirringthe mixture was agitated at -15° C. for 2 hours
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with saturated aqueous solution of sodium chloride
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off in evacuated atomosphere

출처 및 근거

ORD 기록
ord-3ae318039fa6472396b71c8f4c0654bb
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155106

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