Hydrochloric Acid → Sorbitol stearate

HRID 46602

반응식

HRID 46602 반응식
[C:1](Cl)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:21][CH2:22][C@@H:23]([C@H:25]([C@@H:27]([C@@H:29]([CH2:31][OH:32])[OH:30])[OH:28])[OH:26])[OH:24].Cl>C1(C)C=CC=CC=1.N1C=CC=CC=1>[C:1]([OH:19])(=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:32][CH2:31][C@@H:29]([C@H:27]([C@@H:25]([C@@H:23]([CH2:22][OH:21])[OH:24])[OH:26])[OH:28])[OH:30]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 5780SorbitolHCID 8212Stearoyl chloride

생성물 1

HCID 86736698Sorbitol stearate

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 1140Toluene용매

반응 조건

온도
90 °C

실험 절차

411.5 g (1.358 mols) stearic acid chloride are dissolved in 3 l toluene and heated to 90° C. 41.23 g (0.22 mols) of sorbitol, dissolved in 200 ml pyridine are added dropwise to this mixture over 25 minutes. The solution is boiled (at approx. 110° C.) for 1 hour under reflux. After cooling, dilute hydrochloric acid is added to acidify the mixture, which is then washed with water until neutral and dried with dehydrated sodium sulphate. After concentration of the organic phase the sorbitol stearate crystallizes. It is recrystallized from methanol.

후처리

  1. additionare added dropwise to this mixture over 25 minutes
  2. custom(at approx. 110° C.)
  3. customfor 1 hour
  4. temperatureunder reflux
  5. temperatureAfter cooling
  6. washis then washed with water until neutral and
  7. dry with materialdried with dehydrated sodium sulphate
  8. customAfter concentration of the organic phase the sorbitol stearate crystallizes
  9. customIt is recrystallized from methanol

출처 및 근거

ORD 기록
ord-d1dca84c9b584950b7b5fa1a15b7b248
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174325

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