Benzoyl chloride → 5-Chloro-2-oxo-1,2-dihydropyridin-4-yl benzoate

반응식

[Cl:1][C:2]1[C:3]([OH:9])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:10]([O:9][C:3]1[C:2]([Cl:1])=[CH:7][NH:6][C:5](=[O:8])[CH:4]=1)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

반응물 2

HCID 7412Benzoyl chloride

HCID 54679224Gimeracil

생성물 1

HCID 140496465-Chloro-2-oxo-1,2-dihydropyridin-4-yl benzoate수율 37%

실험 절차

Using 1.00 g of 5-chloro-4-hydroxy-2-pyridone and 0.96 ml of benzoyl chloride and following the general procedure of Example 9, 0.64 g of the title compound was produced in a yield of 37%. M.p. 196°-197° C.

출처 및 근거

ORD 기록: ord-984a575eea914a6a9ae7c0b871012d14
출처 데이터셋: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05155113

반응 노트

불러오는 중…