Hydroxyamine hydrochloride → 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

HRID 466191노트

반응식

HRID 466191 반응식
[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=O)=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22]>N1C=CC=CC=1.C(O)C>[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=[N:21][OH:22])=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 149712656-phenoxy-2H-1-benzopyran-3-carboxaldehyde

생성물 1

HCID 856778336-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

시약·촉매·용매 1

HCID 21975839Pyridine ethanol용매

실험 절차

6-Phenoxy-2H-1-benzopyran-3-carboxaldehyde (5.00 g, 19.9 mmol) is dissolved in 175 ml of pyridine/ethanol (1:1) and treated with hydroxylamine hydrochloride (2.07 g, 29.7 mmol). The mixture is stirred for 1 hour and partitioned between ether and water. The aqueous layer is extracted with ether, and the ether layer is washed with 2N HCl, dried (MgSO4) and evaporated to give 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime as a pale yellow solid.

후처리

  1. custompartitioned between ether and water
  2. extractionThe aqueous layer is extracted with ether
  3. washthe ether layer is washed with 2N HCl
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-8e53bd09a0ed4cb3af88766be1a44130
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155130

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