Isobutyl chloroformate → Morphine

HRID 46621

반응식

HRID 46621 반응식
O=[O+][O-].C(C[O:8][C:9]1[CH:10]=[CH:11][C:12]2[CH2:13][C@H:14]3[N:26]([CH3:27])[CH2:25][CH2:24][C@:20]45[C:21]=2[C:22]=1[O:23][C@H:19]4[C@@H:18]([OH:28])[CH:17]=[CH:16][C@@H:15]35)(O)=O.ClC(OCC(C)C)=O.C([O-])(O)=O.[Na+]>CN(C=O)C.O>[CH:11]1[C:12]2[CH2:13][C@H:14]3[N:26]([CH2:25][CH2:24][C@@:20]45[C@H:15]3[CH:16]=[CH:17][C@H:18]([OH:28])[C@@H:19]4[O:23][C:22]([C:21]=25)=[C:9]([OH:8])[CH:10]=1)[CH3:27]

참가 물질

6

반응물 3

HCID 62365Isobutyl chloroformateHCID 516892Sodium BicarbonateHCID 131710346HCID 131710346, 화합물

생성물 1

HCID 5288826Morphine

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

O3 -Carboxymethyl morphine (3.43 g) and 1.31 ml isobutyl chloroformate were combined in 30 ml DMF at 0°. The resulting clear solution was then added to a stirring solution of 2.88 g BSA and 13 g NaHCO3 in 600 ml of water at 0°. Addition was carried out by means of a syringe with its tip below the solution surface. The solution was stirred in a cold room overnight.

후처리

  1. additionAddition
  2. customwas carried out by means of a syringe with its tip below the solution surface

출처 및 근거

ORD 기록
ord-e97ed492edc14387bce9f58b66b21d96
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174384

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