Hydrogen Bromide → 2-Bromo-6-nitro-1-indanone

HRID 46627

반응식

HRID 46627 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][C:10]2=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[BrH:14].BrBr>C(O)(=O)C>[Br:14][CH:9]1[CH2:8][C:7]2[C:11](=[CH:12][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[C:10]1=[O:13]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 905626-Nitroindan-1-one

생성물 1

HCID 110650202-Bromo-6-nitro-1-indanone

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

Analogously to Example 1 (a), reaction of 12.39 g (70.0 mmoles) of 6-nitro-1-indanone in 130 ml of glacial acetic acid, containing 0.5 ml of 48% strength aqueous hydrobromic acid, and 11.2 g (70 mmoles) of bromine in 70 ml of glacial acetic acid, in accordance with the instructions indicated above, gives 2-bromo-6-nitro-1-indanone of melting point 102°-105° C. which, as the pure product after reprecipitation from ethanol/water, has a melting point of 114°-116° C.

출처 및 근거

ORD 기록
ord-95a2c99cc31542a6880abc096cfac5b9
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174397

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