Hydrogen Bromide → 2-Bromo-6-chloro-1-indanone

HRID 46628

반응식

HRID 46628 반응식
[Br:1]Br.[Cl:3][C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][C:10]2=[O:13])=[CH:6][CH:5]=1.Br>C(OC(=O)C)C>[Br:1][CH:9]1[CH2:8][C:7]2[C:11](=[CH:12][C:4]([Cl:3])=[CH:5][CH:6]=2)[C:10]1=[O:13]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 51007056-Chloro-1-indanone

생성물 1

HCID 122065232-Bromo-6-chloro-1-indanone

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of 9.59 g (60.0 mmoles) of bromine in 20 ml of acetic acid ethyl ester is added dropwise to a solution of 10.0 g (60.0 mmoles) of 6-chloro-1-indanone in 80 ml of acetic acid ethyl ester and 0.5 ml of 48% strength aqueous hydrobromic acid. After stirring for 3 hours, the reaction solution is concentrated to dryness, the residue is stirred with 50 ml of water and the precipitate is filtered off. The crude product of melting point 84°-87° is recrystallized from petroleum ether 60/70 and gives the pure product of melting point 92°-94° C.

후처리

  1. concentrationthe reaction solution is concentrated to dryness
  2. stirringthe residue is stirred with 50 ml of water
  3. filtrationthe precipitate is filtered off
  4. customThe crude product of melting point 84°-87° is recrystallized from petroleum ether 60/70
  5. customgives the pure product of melting point 92°-94° C.

출처 및 근거

ORD 기록
ord-840378d0473244f485c09bd95c4d779f
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174397

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