Decanoic Acid → 7-Methyl-2-nonylimidazo[4,5-b]pyridine

HRID 466695

반응식

HRID 466695 반응식
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:9])[CH:5]=[CH:4][N:3]=1.[C:10](O)(=O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>>[CH3:9][C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[N:1]=[C:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[NH:8][C:7]=12

참가 물질

3

반응물 2

HCID 2969Decanoic AcidHCID 3174954-Methylpyridine-2,3-diamine

생성물 1

HCID 190122247-Methyl-2-nonylimidazo[4,5-b]pyridine

실험 절차

The title compound was prepared from 2,3-diamino-4-picoline (0.246 g, 2 mmol) and decanoic acid (0.35 g, 2 mmol) according to the procedure described in Step 1 of Example 9. The crude product was purified by flash chromatography on silica-gel using EtOAc-MeOH (20:1) to give the pure product (0.38 g, 72%) as a tan colored solid.

후처리

  1. customThe crude product was purified by flash chromatography on silica-gel

출처 및 근거

ORD 기록
ord-9163ab4fbd214606bce00d362fc5f7f4
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05157026

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