Propargyl bromide → HCID 15065591, 화합물

HRID 466754노트

반응식

HRID 466754 반응식
[CH2:1](Br)[C:2]#[CH:3].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH2:10])[CH3:6].[CH2:14]1[CH2:18]OC[CH2:15]1>>[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][N:10]([CH2:18][C:14]#[CH:15])[CH2:1][C:2]#[CH:3])[CH3:6].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH:10][CH2:1][C:2]#[CH:3])[CH3:6]

참가 물질

5

반응물 3

HCID 7842Propargyl bromideHCID 8028TetrahydrofuranHCID 695242,2-Diethoxyethylamine

생성물 2

HCID 15065591HCID 15065591, 화합물HCID 15065592HCID 15065592, 화합물

실험 절차

Propargyl bromide (14.7 g of 80% solution in toluene, 0.1 mol) was added to a stirred solution of aminoacetaldehyde diethyl acetal (13.3 g, 0.1 mol) in THF (200 mL). After 2 h the THF was removed and the residual oil was partitioned between ether and sodium hydroxide solution. Evaporation of the ether gave an oil which was chromatographed on silica gel to give 4.7 g of 2,2-diethoxy-N,N-bis-(2-propynyl)ethylamine and 8.1 g of 2,2-diethoxy-N-(2-propynyl)ethylamine.

후처리

  1. customAfter 2 h the THF was removed
  2. customthe residual oil was partitioned between ether and sodium hydroxide solution
  3. customEvaporation of the ether
  4. customgave an oil which
  5. customwas chromatographed on silica gel

출처 및 근거

ORD 기록
ord-0698c25eb20042a9b73206f28b9ad3e5
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05157124

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