Butylamine → N-Butyl-N'-methylurea

280.32 Grams (3.84 moles) of butylamine and 300 ml of dichloromethane were charged to a round bottom flask equipped with stirrer, cold bath, thermometer, addition funnel and reflux condenser. 229.8 Grams (4.03 Moles, a 5% excess) of methyl isocyanate were charged to the addition funnel and added to the flask contents over four hours keeping the contents between 0° and 35° C. After an additional hour of stirring the exothermic reaction subsided and the mixture was allowed to stand overnight.

1. customequipped with stirrer, cold bath
2. additionthermometer, addition funnel
3. temperaturereflux condenser
4. additionadded to the flask contents over four hours
5. customthe contents between 0° and 35° C
6. customthe exothermic reaction

ORD 기록

ord-deac1033c0304fbba96c1259253febb4

출처 데이터셋

uspto-grants-1992_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05158808