1,3-Dibromopropane → 1-(3-Bromopropoxy)-4-fluorobenzene

HRID 467343

반응식

HRID 467343 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:15][CH2:16][CH2:17][CH2:18]Br.C(COC)OC>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][CH2:17][CH2:16][Br:15])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 80011,3-DibromopropaneHCID 80711,2-DimethoxyethaneHCID 97324-FluorophenolHCID 11430Potassium Carbonate

생성물 1

HCID 2600041-(3-Bromopropoxy)-4-fluorobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 11.2 g (0.1 mol) of 4-fluorophenol, 16.5 g (0.12 mol) of pulverized potassium carbonate, 20.2 g (0.1 mol) of 1,3-dibromopropane and 100 ml of anhydrous dimethoxyethane was refluxed under nitrogen for 6 hours and then cooled. The mixture was diluted with methylene chloride and washed with water. The resultant organic product solution was dried over Na2SO4 and evaporated in vacuo. The residue was chromatographed on silica gel using cyclohexane elution to give pure product.

후처리

  1. temperaturewas refluxed under nitrogen for 6 hours
  2. temperaturecooled
  3. washwashed with water
  4. dry with materialThe resultant organic product solution was dried over Na2SO4
  5. customevaporated in vacuo
  6. customThe residue was chromatographed on silica gel
  7. washcyclohexane elution
  8. customto give pure product

출처 및 근거

ORD 기록
ord-60b5ca190a014fdba9710dfad12d80e0
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05159097

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