1,3-Dibromopropane → 1-(3-Bromopropoxy)-4-fluorobenzene
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:15][CH2:16][CH2:17][CH2:18]Br.C(COC)OC>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][CH2:17][CH2:16][Br:15])=[CH:4][CH:3]=1참가 물질
6
실험 절차
A mixture of 11.2 g (0.1 mol) of 4-fluorophenol, 16.5 g (0.12 mol) of pulverized potassium carbonate, 20.2 g (0.1 mol) of 1,3-dibromopropane and 100 ml of anhydrous dimethoxyethane was refluxed under nitrogen for 6 hours and then cooled. The mixture was diluted with methylene chloride and washed with water. The resultant organic product solution was dried over Na2SO4 and evaporated in vacuo. The residue was chromatographed on silica gel using cyclohexane elution to give pure product.
후처리
- temperaturewas refluxed under nitrogen for 6 hours
- temperaturecooled
- washwashed with water
- dry with materialThe resultant organic product solution was dried over Na2SO4
- customevaporated in vacuo
- customThe residue was chromatographed on silica gel
- washcyclohexane elution
- customto give pure product
출처 및 근거
- ORD 기록
- ord-60b5ca190a014fdba9710dfad12d80e0
- 출처 데이터셋
- uspto-grants-1992_10
- 특허 번호
- US05159097
반응 노트
불러오는 중…