Ammonia → 4-Bromo-alpha-methylbenzeneethanamine

HRID 467458

반응식

HRID 467458 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 7363321-(4-Bromophenyl)propan-2-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 2056684-Bromo-alpha-methylbenzeneethanamine

시약·촉매·용매 2

HCID 935Nickel촉매2회HCID 887Methanol용매

실험 절차

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

후처리

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. washThe residue is washed with MeOH
  4. customthe solvent of the filtrate is removed in vacuo
  5. customThe crude product is used without further purification

출처 및 근거

ORD 기록
ord-80508a6c9110408290ac8e22285ba906
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623860B2

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