Acetic Anhydride → N-(1-(4-bromophenyl)propan-2-yl)acetamide

HRID 467459노트

반응식

HRID 467459 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([NH2:18])[CH3:17])=[CH:11][CH:10]=1>CC(O)=O>[Br:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([NH:18][C:5](=[O:7])[CH3:6])[CH3:17])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 2056684-Bromo-alpha-methylbenzeneethanamine

생성물 1

HCID 45824256N-(1-(4-bromophenyl)propan-2-yl)acetamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

17.0 mL (179.7 mmol) acetic anhydride are added to a mixture of 24.2 g (113 mmol) 1-(4-bromophenyl)propane-2-amine and 20 mL AcOH and the reaction mixture is stirred at r.t. over night. The solvent is evaporated in vacuo, and the residue partitonated between TBME and a saturated aq. NaHCO3 solution. The layers are separated and the organic layer is washed with water, dried with Na2SO4, filtered and the solvent is removed in vacuo. The crude product is triturated with DIPE.

후처리

  1. customThe solvent is evaporated in vacuo
  2. customThe layers are separated
  3. washthe organic layer is washed with water
  4. dry with materialdried with Na2SO4
  5. filtrationfiltered
  6. customthe solvent is removed in vacuo
  7. customThe crude product is triturated with DIPE

출처 및 근거

ORD 기록
ord-5ed5faccfa8741a89d4252efa52b52aa
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623860B2

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