Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene

HRID 467461

반응식

HRID 467461 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropane

생성물 1

HCID 156257521-Bromo-4-(cyclopropylmethoxy)benzene

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4, filtered and the solvent is removed in vacuo.

후처리

  1. extractionextracted with DCM
  2. dry with materialThe organic layer is dried with MgSO4
  3. filtrationfiltered
  4. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-e2a0d5eb27f54a2c8c9fae9d97057072
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623860B2

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