Bromomethylcyclopropane → HCID 70097090, 화합물

반응식

[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][NH:8][N:7]=1)=[O:5])[CH3:2].Br[CH2:15][CH:16]1[CH2:18][CH2:17]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[N:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 81503Bromomethylcyclopropane

HCID 178470496HCID 178470496, 화합물

생성물 1

HCID 70097090HCID 70097090, 화합물수율 23%

실험 절차

The product was obtained according to the method described in example 4, step 2 starting from 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester and bromomethyl-cyclopropane as a mixture of regioisomers which were separated by silica gel chromatography using a heptane/ethyl acetate gradient to yield 179 mg (46%) of the desired regioisomer and 88 mg (23%) of 2-cyclopropylmethyl-4-nitro-2H-pyrazole-3-carboxylic acid ethyl ester.

후처리

customThe product was obtained
customwere separated by silica gel chromatography

출처 및 근거

ORD 기록: ord-a8b62b32c10b451e98e15364e4d84975
출처 데이터셋: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08623866B2

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