Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid ethyl ester | HCID 70126398 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
반응 단계
To a stirred suspension of 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid ethyl ester (972 mg, 2.4 mmol) at rt in ethanol (15 ml) under an argon atmosphere was added 1 N NaOH (3 ml, 3.0 mmol). The suspension was stirred at rt for overnight. After the addition of 1 N HCl (3 ml) stirring was continued for 1 hr. The solid was collected by filtration, washed with H2O, then EtOH and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08623866B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-7a8520138c0d4080acfd81771d0a6e02 |
| 출처 메모 | uspto-grants-2014_01 |