Sodium borohydride → 2-(4-Phenoxyphenoxy)cyclopentan-1-ol

HRID 46778노트

반응식

HRID 46778 반응식
[BH4-].[Na+].[O:3]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O.CO>[O:3]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH:16]2[OH:20])=[CH:12][CH:11]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 203857412-(4-Phenoxyphenoxy)-cyclopentan-1-one

생성물 1

HCID 222476762-(4-Phenoxyphenoxy)cyclopentan-1-ol

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 3.78 g of sodium borohydride in 10 ml of water is added at room temperature to a solution of 8.04 g of 2-(4-phenoxyphenoxy)-cyclopentan-1-one in 60 ml of methanol. The reaction mixture is stirred for 15 hours at room temperature and then concentrated under reduced pressure. The residue is poured into ice-water and extracted with ether. The organic phase is washed twice with saturated sodium chloride solution, dried over sodium sulphate and concentrated by rotary evaporation. Fractional distillation of the residue yields 2-(4-phenoxyphenoxy)-cyclopentan-1-ol as a colourless oil with a boiling point of 181°-185° C./0.001 torr.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue is poured into ice-water
  3. extractionextracted with ether
  4. washThe organic phase is washed twice with saturated sodium chloride solution
  5. dry with materialdried over sodium sulphate
  6. concentrationconcentrated by rotary evaporation
  7. distillationFractional distillation of the residue

출처 및 근거

ORD 기록
ord-2ef5f5af53484609ab6d59ece6adafd5
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175137

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