4-Phenoxyphenol → 2-(4-Phenoxyphenoxy)cyclopentan-1-ol

HRID 46781

반응식

HRID 46781 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I-].C([NH+]([CH2:21][CH3:22])CC)C>C(Cl)(Cl)Cl>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([O:14][CH:22]2[CH2:21][CH2:4][CH2:3][CH:2]2[OH:1])=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 132544-PhenoxyphenolHCID 3014304Triethylammonium iodide

생성물 1

HCID 222476762-(4-Phenoxyphenoxy)cyclopentan-1-ol

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
150 °C

실험 절차

A mixture of 18.6 g of 4-phenoxyphenol, 12.8 g of 1,2-carbonyldioxycyclopentane and 4.6 g of triethylammonium iodide is stirred for 7 hours at 150° C. After cooling, the reaction mixture is taken up in chloroform. The solution is washed with water and once with saturated sodium chloride solution, dried over sodium sulphate and concentrated by rotary evaporation. Fractional distillation of the residue yields (2-(4-phenoxyphenoxy)-cyclopentan-1-ol as a colourless oil with a melting point of 181°-185° C./0.001 torr.

후처리

  1. temperatureAfter cooling
  2. washThe solution is washed with water and once with saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated by rotary evaporation
  5. distillationFractional distillation of the residue

출처 및 근거

ORD 기록
ord-548d1b3741fe4d498d99cad709f385ba
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175137

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