2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt

HRID 467825

반응식

HRID 467825 반응식
[O:1]=[C:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].O.[C:9]1(C)C=CC(S(O)(=O)=O)=C[CH:10]=1>C(O)C>[CH2:9]([O:4][C:3](=[O:5])[C:2](=[O:1])[CH2:6][CH3:7])[CH3:10]

참가 물질

4

반응물 2

HCID 582-Oxobutanoic AcidHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 85195ethyl acetoacetate, sodium salt수율 16,662.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Oxo-butyric acid (10.0 g, 97.2 mmol) was dissolved in ethanol (100 mL) and p-toluene sulfonic acid mono hydrate (0.1 g) was added. The reaction mixture was heated to reflux for 48 h. After cooling the reaction mixture to room temperature, the ethanol was removed under reduced pressure to give 11.4 g of 2-oxo-butyric acid ethyl ester.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 48 h
  3. customthe ethanol was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c64981ff2cb44d57a8bca56549480017
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623890B2

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