Bromine → Ethyl 3-bromo-2-oxobutanoate

HRID 467826

반응식

HRID 467826 반응식
[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH2:6][CH3:7])[CH3:2].[Br:10]Br>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH:6]([Br:10])[CH3:7])[CH3:2]

참가 물질

4

반응물 2

HCID 24408BromineHCID 85195ethyl acetoacetate, sodium salt

생성물 1

HCID 11117285Ethyl 3-bromo-2-oxobutanoate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The 2-oxo-butyric acid ethyl ester prepared above was dissolved in chloroform (100 mL) and bromine (20.964 g, 131.19 mmol) was added dropwise at room temperature. The reaction mixture was allowed to stir for 18 h. Concentration of the reaction mixture under reduced pressure provided 12.0 g of the title compound as an orange oil. 1H NMR (CDCl3) δ 4.39 (q, 2H), 4.32 (q, 1H), 1.88 (d, 3H), 1.39 (t, 3H).

출처 및 근거

ORD 기록
ord-51550b5f38fd48ef9682d22e4781c513
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623890B2

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