Sodium Hydroxide → HCID 43566624, 화합물

HRID 468177노트

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HRID 468177 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]3[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:11]=3[N:10]=[CH:9]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59625812HCID 59625812, 화합물

생성물 1

HCID 43566624HCID 43566624, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 60e (0.18 g, 0.666 mmol) in EtOH (10 mL) was added 1N aqueous NaOH (2.5 mL, 2.5 mmol). The mixture was stirred at room temperature for 4 d. The solvent was evaporated and 1N aqueous HCl was added, followed by extraction with EtOAc. The organic layer was dried over MgSO4 and concentrated. The crude product 60f was purified by preparative reverse phase chromatography. MS m/z (M+H+) 257.1.

후처리

  1. customThe solvent was evaporated
  2. addition1N aqueous HCl was added
  3. extractionfollowed by extraction with EtOAc
  4. dry with materialThe organic layer was dried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product 60f was purified by preparative reverse phase chromatography

출처 및 근거

ORD 기록
ord-70e98bbd315e4384912080cda7e37e2b
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623858B2

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