Ammonium Chloride → (7-Chloro-1,3-dioxaindan-5-yl)methanol
반응식
[Cl:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]=[O:12])[CH:3]=1.[BH4-].[Na+].[NH4+].[Cl-]>C1COCC1>[Cl:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH2:11][OH:12])[CH:3]=1참가 물질
5
실험 절차
To a solution of 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde (6.0 g, 33 mmol) in THF (50 mL) was added NaBH4 (2.5 g, 64 mmol)) in portions at 0° C., The mixture was stirred at this temperature for 30 mm and then poured into aqueous NH4Cl solution. The organic layer was separated, and the aqueous phase was extracted with EtOAc (50 mL×3). The combined extracts were dried over Na2SO4 and evaporated under reduced pressure to afford (7-chlorobenzo[d][1,3]dioxol-5-yl)methanol, which was directly used in the next step.
후처리
- customThe organic layer was separated
- extractionthe aqueous phase was extracted with EtOAc (50 mL×3)
- dry with materialThe combined extracts were dried over Na2SO4
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-721d231310dc4dd9a0ca9c705dbd586e
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08623905B2
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