Chlorosulfonyl isocyanate → 6-Nitro-1H-indole-3-carbonitrile

HRID 468388

반응식

HRID 468388 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].ClS([N:17]=[C:18]=O)(=O)=O.C([O-])(O)=O.[Na+]>CN(C=O)C.CC#N>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([C:18]#[N:17])=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 70918Chlorosulfonyl isocyanateHCID 785026-Nitro-1H-indoleHCID 516892Sodium Bicarbonate

생성물 1

HCID 2831796-Nitro-1H-indole-3-carbonitrile수율 82%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매2회

실험 절차

To a solution of 6-nitroindole (4.9 g 30 mmol) in DMF (24 mL) and CH3CN (240 mL) was added dropwise a solution of ClSO2NCO (5.0 mL) in CH3CN (39 mL) at 0° C. After addition, the reaction was allowed to warm to room temperature and was stirred for 2 h. The mixture was then poured into ice-water and basified with sat, NaHCO3 solution to pH 7-8. The mixture was extracted with ethyl acetate. The organics were washed with brine, dried over Na2SO4 and concentrated to give 6-nitro-1H-indole-3-carbonitrile (4.6 g, 82%).

후처리

  1. additionAfter addition
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe organics were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9554f48720404e48ac290cebd739065e
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623905B2

연결된 노트

불러오는 중…