Sodium Hydroxide → 3-Chloro-2,2-dimethylbut-3-enoic acid
반응식
[Cl:1][C:2](=[CH2:10])[C:3]([CH3:9])([CH3:8])[C:4]([O:6]C)=[O:5].[OH-].[Na+]>O>[Cl:1][C:2](=[CH2:10])[C:3]([CH3:9])([CH3:8])[C:4]([OH:6])=[O:5]참가 물질
4
실험 절차
A mixture of methyl 3-chloro-2,2-dimethylbut-3-enoate (42.0 g, 0.26 mol) and NaOH (12.4 g, 031 mol) in water (300 mL) was heated at reflux overnight. After cooling, the reaction mixture was extracted with ether. The organic layer contained 20 g of methyl 3-chloro-2,2-dimethylbut-3-enoate (48% recovered). The aqueous layer was acidified with cold 20% HCl solution and was extracted with ether (250 mL×3). The combined organic layers were dried and evaporated under reduced pressure to give 3-chloro-2,2-dimethylbut-3-enoic acid (17 g, 44%), which was used directly in the next step.
후처리
- temperaturewas heated
- temperatureat reflux overnight
- temperatureAfter cooling
- extractionthe reaction mixture was extracted with ether
- extractionwas extracted with ether (250 mL×3)
- customThe combined organic layers were dried
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-c673632a67c3427986008d179b470cd2
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08623905B2
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