Ammonium Hydroxide → 2-Amino-4-chloropyrimidine

반응식

[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[OH-].[NH4+:10]>>[NH2:10][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[Cl:1][C:2]1[N:7]=[C:6]([NH2:10])[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 775312,4-Dichloropyrimidine

생성물 2

HCID 2233322-Amino-4-chloropyrimidine

HCID 3457522-Chloro-4-aminopyrimidine

실험 절차

To 2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was added 28% w/v ammonium hydroxide solution (20 mL). The mixture was stirred overnight at ambient temperature then concentrated in vacuo. The residue was dry loaded and purified by FCC eluting with 2-10% EtOH in CHCl3 to afford 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine.