Dichloromethane → tert-Butyl 4-[(4-{[5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazol-2-yl]carbonyl}piperazin-1-yl)methyl]piperidine-1-carboxylate

4-Methoxy-N,2,6-trimethyl-N-{[5-(piperazin-1-ylcarbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide (0.2 g, 0.44 mmol) and tert-butyl 4-formylpiperidine-1-carboxylate (0.14 g, 0.66 mmol) were dissolved in DCE (4 mL) and a few 4 Å molecular sieves added. The reaction was stirred for 30 min at ambient temperature prior to addition of STAB (0.28 g, 1.3 mmol). The reaction was stirred for 18 h, diluted with MeOH (0.5 mL) and concentrated in vacuo. The residue was redissolved in DCM (5 mL) and filtered through Celite, washing with DCM. The DCM solution was treated with acetic anhydride (0.1 mL, 1.0 mmol) and stirred for 30 min at ambient temperature. The solvent was removed in vacuo and the residue redissolved in MeOH (2 mL) and the solution absorbed on to a 2 g SCX cartridge. The sorbent was washed with MeOH (10 mL) and the product eluted with 7 N NH3 in MeOH (10 mL). The solvent was removed in vacuo to afford the title compound.

1. additiona few 4 Å molecular sieves added
2. additionto addition of STAB (0.28 g, 1.3 mmol)
3. stirringThe reaction was stirred for 18 h
4. concentrationconcentrated in vacuo
5. dissolutionThe residue was redissolved in DCM (5 mL)
6. filtrationfiltered through Celite
7. washwashing with DCM
8. stirringstirred for 30 min at ambient temperature
9. customThe solvent was removed in vacuo
10. dissolutionthe residue redissolved in MeOH (2 mL)
11. customthe solution absorbed on to a 2 g SCX cartridge
12. washThe sorbent was washed with MeOH (10 mL)
13. washthe product eluted with 7 N NH3 in MeOH (10 mL)
14. customThe solvent was removed in vacuo

ORD 기록

ord-64b1f93acff8485a91c06115aa95b1d9

출처 데이터셋

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08623859B2