Aluminum(III) Chloride → 6-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

HRID 469326노트

반응식

HRID 469326 반응식
Cl.[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:11]=1)[C:8](Cl)=[O:9].[CH3:12][C:13]1[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[Br:2][C:3]1[CH:11]=[C:7]([C:8]([C:15]2[CH:14]=[C:13]([CH3:12])[C:18]3[NH:19][C:20](=[O:22])[O:21][C:17]=3[CH:16]=2)=[O:9])[CH:6]=[N:5][CH:4]=1

참가 물질

4

반응물 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 189717365-Bromo-nicotinic acid chloride hydrochloride

생성물 1

HCID 581811166-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

실험 절차

2.57 g (10.0 mmol) 5-bromo-nicotinic acid chloride hydrochloride, 1.49 g (10.0 mmol) 4-methyl-3H-benzoxazol-2-one and 5.33 g (40.0 mmol) aluminium trichloride were heated to 125° C. with stirring for 1.5 h. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

후처리

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried i

출처 및 근거

ORD 기록
ord-708df34646e244ee8b57dd9f0e41748c
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629137B2

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