Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-4-fluorobenzoyl chloride → 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-4-fluorobenzoyl chloride | HCID 69598 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 4-Methyl-3H-benzooxazol-2-one | HCID 12709336 | — |
| 생성물 | 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one | HCID 58181165 | — |
반응 단계
2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08629137B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-f0500187676c41158cfad604f0265059 |
| 출처 메모 | uspto-grants-2014_01 |