Aluminum(III) Chloride → 2-Fluoro-4-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile

HRID 469342노트

반응식

HRID 469342 반응식
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].[CH3:13][C:14]1[C:19]2[NH:20][C:21](=[O:23])[O:22][C:18]=2[CH:17]=[CH:16][CH:15]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[F:12][C:4]1[CH:5]=[C:6]([C:7]([C:16]2[CH:15]=[C:14]([CH3:13])[C:19]3[NH:20][C:21](=[O:23])[O:22][C:18]=3[CH:17]=2)=[O:8])[CH:10]=[CH:11][C:3]=1[C:1]#[N:2]

참가 물질

4

반응물 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 199567394-Cyano-3-fluorobenzoyl chloride

생성물 1

HCID 581811882-Fluoro-4-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile

실험 절차

0.73 g (4.0 mmol) 4-cyano-3-fluoro-benzoic acid chloride, 0.60 g (4.0 mmol) 4-methyl-3H-benzoxazol-2-one and 2.1 g (16 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was combined with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

후처리

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried i

출처 및 근거

ORD 기록
ord-844e169c07544f8e87ce02a2ab47f45d
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629137B2

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