7-Methylisatin → 2H-Indol-2-one, 1,3-dihydro-7-methyl-

HRID 469358노트

반응식

HRID 469358 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=O.O.NN>>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2

참가 물질

3

반응물 2

HCID 143137-MethylisatinHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 30142252H-Indol-2-one, 1,3-dihydro-7-methyl-

실험 절차

5.00 g (31.0 mmol) 7-methyl-1H-indol-2,3-dione in 18.1 mL (372 mmol) hydrazine hydrate were heated to 110° C. for 3 h. Then the reaction mixture was cooled, the precipitate formed was suction filtered and washed with water. The precipitate was suspended in water, acidified with conc. hydrochloric acid and stirred for 10 min. Then the reaction mixture was stirred for a further 30 min in the ice bath, the precipitate was suction filtered, washed with water and dried.

후처리

  1. temperatureThen the reaction mixture was cooled
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. stirringThen the reaction mixture was stirred for a further 30 min in the ice bath
  6. filtrationfiltered
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-359fa9febe914ddb907f15fe88f97ad9
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629137B2

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