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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Diisopropylethylamine → 6-[4-(7-Methoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acidmethoxy-methyl-amide

HRID 469371
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인쇄 미리보기

반응식

HRID 469371 반응식
[CH3:1][O:2][N:3]([CH3:13])[C:4]([C:6]1[CH:11]=[C:10](Cl)[N:9]=[CH:8][N:7]=1)=[O:5].[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:19]2[NH:25][C:24](=[O:26])[N:23]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[CH2:22][CH2:21][C:20]=2[CH:33]=1.CCN(C(C)C)C(C)C>C1COCC1.O>[CH3:1][O:2][N:3]([CH3:13])[C:4]([C:6]1[CH:11]=[C:10]([N:30]2[CH2:29][CH2:28][CH:27]([N:23]3[CH2:22][CH2:21][C:20]4[CH:33]=[C:16]([O:15][CH3:14])[CH:17]=[CH:18][C:19]=4[NH:25][C:24]3=[O:26])[CH2:32][CH2:31]2)[N:9]=[CH:8][N:7]=1)=[O:5]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 183568527-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 581812166-Chloro-pyrimidine-4-carboxylic acidmethoxy-methyl-amide

생성물 1

HCID 581811336-[4-(7-Methoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acidmethoxy-methyl-amide

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8028Tetrahydrofuran용매

실험 절차

0.20 g (0.99 mmol) 6-chloro-pyrimidine-4-carboxylic acidmethoxy-methyl-amide, 0.28 g 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one and 0.20 mL (1.16 mmol) DIPEA in 1.5 mL THF were heated to 120° C. in the microwave for 30 min. The mixture was diluted with water and extracted with DCM. The combined organic phases were dried on sodium sulphate, filtered and evaporated down i. vac. The residue was triturated with diethyl ether, suction filtered and dried.

후처리

  1. extractionextracted with DCM
  2. customThe combined organic phases were dried on sodium sulphate
  3. filtrationfiltered
  4. customevaporated down i
  5. customThe residue was triturated with diethyl ether, suction
  6. filtrationfiltered
  7. customdried

출처 및 근거

ORD 기록
ord-3236cce6c4b142b195a693cfeb07c18e
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08629137B2

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