Trifluoroacetic anhydride → Pga1

HRID 46949

반응식

HRID 46949 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C@@H:9]1[C@@H:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:12](=[O:13])[CH2:11][C@H:10]1O.FC(F)(F)C(OC(=O)C(F)(F)F)=O>N1C=CC=CC=1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C@@H:9]1[C@@H:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:12](=[O:13])[CH:11]=[CH:10]1

참가 물질

4

반응물 2

HCID 9845Trifluoroacetic anhydrideHCID 5280723Alprostadil

생성물 1

HCID 5281912Pga1

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Alternately, the PGE1 -type compound is transformed to a bis-trifluoroacetate, for example by reaction with trifluoroacetic anhydride in the presence of pyridine in a solvent at 0° to 5° C., and thereafter contacted with a low-boiling alcohol (preferably b.p. below 110° C.) with a tertiary amine to form a PGA1 -type compound.

출처 및 근거

ORD 기록
ord-a11fac49e947493ab26228d4b32a677d
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175202

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