Sodium Hydroxide → (S)-1-(4-methoxybenzyl)-octahydroisoquinoline

HRID 4696노트

반응식

HRID 4696 반응식
C([O-])(=O)C.[CH3:5][O:6][C:7]1[CH:23]=[CH:22][C:10]([CH2:11][C@H:12]2[C:21]3[CH:16]([CH2:17][CH2:18][CH2:19][CH:20]=3)[CH2:15][CH2:14][NH2+:13]2)=[CH:9][CH:8]=1.[OH-].[Na+]>O>[CH3:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][C@H:12]2[C:21]3[CH:16]([CH2:17][CH2:18][CH2:19][CH:20]=3)[CH2:15][CH2:14][NH:13]2)=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18611875(S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate

생성물 1

HCID 18611876(S)-1-(4-methoxybenzyl)-octahydroisoquinoline수율 97.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 31.7 g of (S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate in 250 ml of water is brought by addition of concentrated sodium hydroxide solution to pH 12. The free base is extracted twice with 150 ml of diethyl ether each time. Washing of the combined extracts with water, drying over sodium sulfate and removal of the solvent in vacuo leaves 25.0 g (97.3% of theory) of (S)-1-(4-methoxybenzyl)-octahydroisoquinoline.

후처리

  1. extractionThe free base is extracted twice with 150 ml of diethyl ether each time
  2. washWashing of the combined extracts with water
  3. dry with materialdrying over sodium sulfate and removal of the solvent in vacuo

출처 및 근거

ORD 기록
ord-8be19d99101940f8b611464ff0ecf239
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727147

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