Methyl iodide → 7-Bromo-2-(methylthio)benzo[d]oxazole

HRID 469822노트

반응식

HRID 469822 반응식
[Br:1][C:2]1[C:10]2[O:9][C:8]([SH:11])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:12]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C>[Br:1][C:2]1[C:10]2[O:9][C:8]([S:11][CH3:12])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527769HCID 178527769, 화합물

생성물 1

HCID 674568117-Bromo-2-(methylthio)benzo[d]oxazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 6 g (26.1 mmol) 7-bromo-benzooxazole-2-thiol, 7.28 g (52.2 mmol) K2CO3, 4.1 g (28.7 mmol) MeI in 80 ml DMF is stirred at room temperature for 1 h. The reaction mixture is then poured on water and extracted 2× with EtOAc. The combined organic layers are washed with water and saturated NaCl solution, dried over MgSO4, filtered and the filtrate is concentrated in vacuo to afford the title compound.

후처리

  1. additionThe reaction mixture is then poured on water
  2. extractionextracted 2× with EtOAc
  3. washThe combined organic layers are washed with water and saturated NaCl solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-c25e223ba1c24721a93ba704c882b175
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629168B2

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