Tetrahydrofuran → 2-Amino-6-bromophenol

HRID 469824

반응식

HRID 469824 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11].C1COCC1>CO.[Ni]>[NH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[C:3]=1[OH:11]

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 135454532-Bromo-6-nitrophenol

생성물 1

HCID 155315062-Amino-6-bromophenol

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of 5.3 g (22.7 mmol) 2-bromo-6-nitro-phenol in 100 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g Ra—Ni (in EtOH, Degussa B113W). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.

후처리

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-26bd5e9dcb284bcea424992ae7e1b2c8
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629168B2

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