Water → [2-(3-Hydroxypropyl)phenyl]acetic acid

HRID 46991노트

반응식

HRID 46991 반응식
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]#N.[OH-:14].[Na+].[OH2:16]>C(O)C>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([OH:16])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22645929[2-(3-Hydroxypropyl)phenyl]acetonitrile

생성물 1

HCID 20386052[2-(3-Hydroxypropyl)phenyl]acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of [2-(3-hydroxypropyl)phenyl]acetonitrile (52.5 g., 0.30 mole) and sodium hydroxide (40 g., 1.0 mole) in water (200 ml.) and ethanol (600 ml.) is heated at reflux for 18 hours. The solution is concentrated in vacuo to about half-volume. Water (600 ml.) is added and the resulting solution is acidified with 6 N hydrochloric acid. The precipitated product acid is taken up in ether, washed with water, and dried over magnesium sulfate. The ether is evaporated in vacuo to afford [2-(3-hydroxypropyl)phenyl]acetic acid.

후처리

  1. temperatureat reflux for 18 hours
  2. concentrationThe solution is concentrated in vacuo to about half-volume
  3. additionWater (600 ml.) is added
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. customThe ether is evaporated in vacuo

출처 및 근거

ORD 기록
ord-8c9af75524ad440a9b8550e0f9c53c25
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175203

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