2-Fluoroaniline → 4-Bromo-2-fluoroaniline

HRID 47007

반응식

HRID 47007 반응식
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>C(Cl)Cl>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[CH:16]=1

참가 물질

4

반응물 2

HCID 95842-FluoroanilineHCID 67184N-bromobutanimide

생성물 1

HCID 1230504-Bromo-2-fluoroaniline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

160 Parts of solid N-bromosuccinimide were added in portions over a 2 hour period to a solution of 100 parts of 2-fluoroaniline in 400 parts of methylene chloride cooled to 0°. After stirring for 20 minutes, the dark red mixture was washed four times; 200 parts of cold water were used for each washing. The red organic phase was dried with anhydrous sodium sulfate and evaporated at 300 mm.Hg to yield 164 parts of brown, oily 4-bromo-2-fluoroaniline, nD25 : 1.5885.

후처리

  1. temperaturecooled to 0°
  2. washthe dark red mixture was washed four times
  3. dry with materialThe red organic phase was dried with anhydrous sodium sulfate
  4. customevaporated at 300 mm.Hg

출처 및 근거

ORD 기록
ord-637cb1ab1673407aa14706e6cc2e10fc
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175948

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