Hydrochloric Acid → 1,3,8-Trihydroxy-6-methyl-9(10H)-anthracenone

HRID 470658

반응식

HRID 470658 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]2[C:9]([C:11]3[C:16]([OH:17])=[CH:15][C:14]([OH:18])=[CH:13][C:12]=3[C:19](=O)[C:4]=2[CH:3]=1)=[O:10].Cl>C(O)(=O)C>[CH3:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]2[C:9]([C:11]3[C:16]([OH:17])=[CH:15][C:14]([OH:18])=[CH:13][C:12]=3[CH2:19][C:4]=2[CH:3]=1)=[O:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric Acid2회HCID 3220Emodin

생성물 1

HCID 1226351,3,8-Trihydroxy-6-methyl-9(10H)-anthracenone수율 95.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 20 grams of emodin, 1000 mL of acetic acid, 82.8 grams of stannous chloride was heated to reflux. Hydrochloric acid (60 mL) was added slowly in minutes and continued reflux for 1 hour. Remaining 167 mL of HCl was added slowly at reflux and continued for an additional 1 hour. Orange color mixture was cooled to room temperature and left over night. Product was isolated by filtration and washed with water. Finally the product (emodin anthrone) was dried in vacuo at 60° C. to a constant weight to afford 18.1 grams (Yield: 95%) of an orange powder.

후처리

  1. temperaturewas heated to reflux
  2. temperaturecontinued reflux for 1 hour
  3. additionwas added slowly
  4. temperatureat reflux
  5. waitleft over night
  6. customProduct was isolated by filtration
  7. washwashed with water
  8. dry with materialFinally the product (emodin anthrone) was dried in vacuo at 60° C. to a constant weight

출처 및 근거

ORD 기록
ord-6f789f8da53a432bad8ff41fd920e6e6
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629302B2

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