Ethyl 2-(2,2,2-trifluoroethyl)thiazole-4-carboxylate → 2-(2,2,2-Trifluoroethyl)-1,3-thiazole-4-carboxylic acid
반응식
[F:1][C:2]([F:15])([F:14])[CH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9]([O:11]CC)=[O:10])[N:8]=1>Cl.O>[F:15][C:2]([F:1])([F:14])[CH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9]([OH:11])=[O:10])[N:8]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of ethyl 2-(2,2,2-trifluoroethyl)thiazole-4-carboxylate (example 67, step c) (0.3 g) in concentrated hydrochloric acid (7 mL) and water (7 mL) was heated at 80° C. for 5 hours under nitrogen. The solvent was evaporated under a stream of nitrogen and the residue partitioned between ethyl acetate (40 mL) and brine (3 mL). The organic layer was dried over sodium sulphate, filtered and the solvent evaporated under reduced pressure to afford the subtitled compound. Yield 0.23 g.
후처리
- customThe solvent was evaporated under a stream of nitrogen
- customthe residue partitioned between ethyl acetate (40 mL) and brine (3 mL)
- dry with materialThe organic layer was dried over sodium sulphate
- filtrationfiltered
- customthe solvent evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-3ad11f1093ed4264bb13410edb2826a8
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629271B2
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