Hydrochloric Acid → 2-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

HRID 471169

반응식

HRID 471169 반응식
Cl.C([O:4][CH:5](OCC)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[C:10]([F:17])[C:9]=1[F:18])C>O1CCOCC1.O>[F:18][C:9]1[C:10]([F:17])=[C:11]([CH2:14][CH2:15][OH:16])[CH:12]=[CH:13][C:8]=1[O:7][CH2:6][CH:5]=[O:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 579889892-(4-(2,2-Diethoxyethoxy)-2,3-difluorophenyl)ethanol

생성물 1

HCID 866367532-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)-2,3-difluorophenyl)ethanol (example 77, step c) (0.49 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The mixture was carefully diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound, which was used directly. Yield 0.31 g.

후처리

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. washThe combined organics were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-d9371c8a2384405bb422374284e2c1fb
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629271B2

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