Methyl iodide → 2-Isopropylpyridine

HRID 471192

반응식

HRID 471192 반응식
[CH2:1]([Li])CCC.[CH2:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:7].CI>O1CCCC1>[CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:1])[CH3:7]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 75232-EthylpyridineHCID 178418339Butyllithium

생성물 1

HCID 695232-Isopropylpyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of butyllithium (1.6M in hexanes, 50 mL) was added dropwise over 20 min to a solution of 2-ethylpyridine (9.34 mL) in tetrahydrofuran (50 mL) at −70° C. The mixture was stirred for 2 h then methyl iodide (5 mL) was added dropwise over 15 min. The resulting orange slurry was allowed to warm to RT and stirred overnight. The solvent was evaporated and the residue diluted with diethylether (100 mL). The organic layer was washed with water (2×100 mL) and brine (100 mL), then dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a yellow oil. Yield 9.1 g.

후처리

  1. stirringstirred overnight
  2. customThe solvent was evaporated
  3. additionthe residue diluted with diethylether (100 mL)
  4. washThe organic layer was washed with water (2×100 mL) and brine (100 mL)
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-cc37459afe1643b99fc32b60888ac2a4
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08629271B2

연결된 노트

불러오는 중…