4-[[(6-chloropyridin-3-yl)methyl](methyl)amino]furan-2(5H)-one → Rotenone

HRID 471332

반응식

HRID 471332 반응식
BrC1N=CC(CN(CCF)[C:10]2[CH2:14][O:13][C:12](=O)[CH:11]=2)=CC=1.FC1N=CC(CN(CC(F)F)[C:28]2[CH2:32][O:31][C:30](=[O:33])[CH:29]=2)=CC=1.ClC1SC(CN(CCF)[C:46]2[CH2:50][O:49][C:48](=O)[CH:47]=2)=CN=1.ClC1N=CC(CN(CCF)[C:64]2[CH2:68][O:67][C:66](=O)[CH:65]=2)=CC=1.ClC1N=CC(CN(CC(F)F)[C:82]2[CH2:86][O:85][C:84](=O)[CH:83]=2)=CC=1.Cl[C:93]1N=CC(CN(C)C2COC(=O)C=2)=[CH:95][C:94]=1F.ClC1C=C(CN(CCF)C2COC(=O)C=2)C=NC=1Cl.ClC1N=CC(CN(C2CC2)C2COC(=O)C=2)=CC=1F.ClC1N=CC(CN(C2CC2)C2COC(=O)C=2)=CC=1.ClC1N=CC(CN(C)C2COC(=O)C=2)=CC=1.ClC1N=CC(CCS([O-])=NC#N)=CC=1.ClC1N=CC(C(CS([O-])=NC#N)C)=CC=1>>[CH3:95][C:94]([C@@H:12]1[O:13][C:14]2[CH:86]=[CH:82][C:83]3[C:30](=[O:33])[C@@H:29]4[C@@H:28]([CH2:32][O:31][C:65]5[C:47]4=[CH:46][C:50]([O:49][CH3:48])=[C:68]([O:67][CH3:66])[CH:64]=5)[O:85][C:84]=3[C:10]=2[CH2:11]1)=[CH2:93]

참가 물질

13

반응물 12

HCID 115504594-[[(6-chloropyridin-3-yl)methyl](methyl)amino]furan-2(5H)-oneHCID 167505614-{[(6-Chloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5h)-oneHCID 16752772FlupyradifuroneHCID 167527734-[[(5,6-Dichloropyridin-3-yl)methyl](2-fluoroethyl)amino]furan-2(5H)-oneHCID 251028324-{[(6-Fluoropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5h)-oneHCID 251910444-[[(6-Chloro-5-fluoropyridin-3-yl)methyl](methyl)amino]furan-2(5h)-oneHCID 252274114-[[(6-chloropyridin-3-yl)methyl](2-fluoroethyl)amino]furan-2(5H)-oneHCID 446094224-{[(6-Bromopyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5h)-oneHCID 462218884-{[(2-Chloro-1,3-thiazol-5-yl)methyl](2-fluoroethyl)amino}furan-2(5h)-oneHCID 462218894-{[(6-Chloro-5-fluoropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5h)-oneHCID 131730852[(6-Chloropyridin-3-yl)methyl](methyl)oxido-lambda4-sulphanylidenecyanamideHCID 131730854[1-(6-Chloropyridin-3-yl)ethyl](methyl)oxido-lambda4-sulphanylidenecyanamide

생성물 1

HCID 6758Rotenone

실험 절차

4-{[(6-bromopyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(6-fluoropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(2-chloro-1,3-thiazol-5-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(6-chloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115644), 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one (known from WO 2007/115643), 4-{[(5,6-dichloropyrid-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (known from WO 2007/115646), 4-{[(6-chloro-5-fluoropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one (known from WO 2007/115643), 4-{[(6-chloropyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one (known from EP-A-0 539 588), 4-{[(6-chloropyrid-3-yl)methyl](methyl)amino}furan-2(5H)-one (known from EP-A-0 539 588), [(6-chloropyridin-3-yl)methyl](methyl)oxido-λ4-sulphanylidenecyanamide (known from WO 2007/149134), [1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-λ4-sulphanylidenecyanamide (known from WO 2007/149134) and its diastereomers (A) and (B)

출처 및 근거

ORD 기록
ord-81077173f9f74c7bbf0fb46479c24e26
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08632767B2

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