Water → 1H-Inden-1-one, 4-bromo-2,3-dihydro-5-(trifluoromethyl)-

HRID 471459노트

반응식

HRID 471459 반응식
[Br:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][CH2:13][C:14]([OH:16])=O.O>FC(F)(F)S(O)(=O)=O>[Br:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[C:4]2[C:3]=1[CH2:12][CH2:13][C:14]2=[O:16]

참가 물질

4

반응물 2

HCID 962WaterHCID 53808869Benzenepropanoic acid, 2-bromo-3-(trifluoromethyl)-

생성물 1

HCID 867007731H-Inden-1-one, 4-bromo-2,3-dihydro-5-(trifluoromethyl)-

시약·촉매·용매 1

HCID 62406Trifluoromethanesulfonic acid용매

반응 조건

온도
85 °C

실험 절차

3-(2-Bromo-3-trifluoromethyl-phenyl)-propionic acid (3.0 g, 10.1 mmol) is suspended in trifluoromethanesulfonic acid (30 mL)) under argon and heated at 85° C. for 4 hours. The mixture is added dropwise to iced water and then extracted with ethyl acetate. The organic extract is washed with saturated sodium bicarbonate solution, dried and concentrated under vacuum. The residue is purified by flash chromatography (Eluent 0-5% EtOAc in cyclohexane) to give the title compound.

후처리

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. washis washed with saturated sodium bicarbonate solution
  4. customdried
  5. concentrationconcentrated under vacuum
  6. customThe residue is purified by flash chromatography (Eluent 0-5% EtOAc in cyclohexane)

출처 및 근거

ORD 기록
ord-962ec0282eea4bd1935c15bb6dfbed29
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08633182B2

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