Sodium Hydroxide → Topiramate sodium trihydrate

HRID 47194노트

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HRID 47194 반응식
[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH2:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:15])([CH3:14])[O:11][C@H:8]32)[O:3]1.[OH-:23].[Na+:24]>O>[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH-:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:14])([CH3:15])[O:11][C@H:8]32)[O:3]1.[OH2:23].[OH2:3].[OH2:3].[Na+:24]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 5284627Topiramate2회

생성물 1

HCID 72941832Topiramate sodium trihydrate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

0.97 g (2.9 mmols) of topiramate (Cheminor Ltd.), 10 mL distilled water, and 2.8 mL IN NaOH (2.8 mmol) were added to a glass beaker, warmed on a hotplate to 60° C. and stirred with a TEFLON-coated stir bar on a magnetic stirplate. The solid topiramate dissolved in about 25 minutes.

후처리

  1. additionwere added to a glass beaker

출처 및 근거

ORD 기록
ord-26a5cce085ee4a79a68469de484ba26c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699840B2

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