Nitric Acid → HCID 178512554, 화합물

HRID 47202노트

반응식

HRID 47202 반응식
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[N+:10]([O-:13])([OH:12])=[O:11].[N:14]#[C:15][NH2:16]>CCO>[N+:10]([O-:13])([OH:12])=[O:11].[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:15]([NH2:16])=[NH:14]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 97092,4-DifluoroanilineHCID 9864Cyanamide

생성물 1

HCID 178512554HCID 178512554, 화합물수율 40%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of 2,4-difluoroaniline (25 mmol, 3.2 g) in EtOH (10 mL) in an ice bath was added nitric acid (69% aq soln.; 1.8 mL) dropwise. After completion of the addition cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 22 h. The solvent was evaporated. The solid residue was washed with EtOH and was dried under high vacuum to afford the title compound as a purple solid (2.32 g, 40%).

후처리

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed under N2 for 22 h
  3. customThe solvent was evaporated
  4. washThe solid residue was washed with EtOH
  5. customwas dried under high vacuum

출처 및 근거

ORD 기록
ord-f864972e90794ee39827fc1c7b384905
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699854B2

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