Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 47274

반응식

HRID 47274 반응식
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

참가 물질

3

반응물 2

HCID 14923Ammonium Hydroxide2회HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

생성물 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

실험 절차

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

후처리

  1. temperatureheating

출처 및 근거

ORD 기록
ord-b966538370894aab817f4a3432f2391f
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699866B2

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