Methanol → 2-(4,5-dihydro-1H-imidazol-2-yl)benzenethiol

HRID 47284

반응식

HRID 47284 반응식
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].[CH2:11]([NH2:14])[CH2:12][NH2:13].CO>ClC1C=CC=CC=1Cl>[NH:13]1[CH2:12][CH2:11][N:14]=[C:1]1[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[SH:4]

참가 물질

5

반응물 3

HCID 887MethanolHCID 3301EthylenediamineHCID 54432-Mercaptobenzoic Acid

생성물 1

HCID 14773612-(4,5-dihydro-1H-imidazol-2-yl)benzenethiol수율 53.1%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

반응 조건

온도
60 °C

실험 절차

To a suspension of 20.0 g (0.112 mol) of thiosalicylic acid in 200 mL of 1,2-dichlorobenzene was added 21.6 mL (0.323 mol) of ethylenediamine. The mixture was refluxed under nitrogen for 4 h then cooled to ca. 60° C. and 50 mL of methanol was added. The solution was allowed to stand at 22° C. over night and the resulting yellow crystalline solid collected and washed with ether to give 10.6 g of pure product.

후처리

  1. temperatureThe mixture was refluxed under nitrogen for 4 h
  2. waitto stand at 22° C. over night
  3. customthe resulting yellow crystalline solid collected
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-4a87912f4f5b4b53b7be1e8d5a52c856
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699873B1

연결된 노트

불러오는 중…