Methyl iodide → 1-Methoxy-2-(trifluoromethyl)benzene

HRID 47293

반응식

HRID 47293 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[C:12](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:12]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 679582-Trifluoromethylphenol

생성물 1

HCID 27752511-Methoxy-2-(trifluoromethyl)benzene수율 111.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 10 g 2-trifluoromethyl phenol, 17 g potassium carbonate, 150 ml acetone and 7.7 ml iodomethane was heated under reflux for 2 hr. After cooling, the insoluble matters were removed by filtration, and the filtrate was evaporated. The resulting residue was dissolved in ethyl acetate, and washed with water and brine. It was dried over anhydrous magnesium sulfate, filtered, and evaporated to give 12.15 g of 2-trifluoromethyl anisole.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hr
  3. temperatureAfter cooling
  4. customthe insoluble matters were removed by filtration
  5. customthe filtrate was evaporated
  6. dissolutionThe resulting residue was dissolved in ethyl acetate
  7. washwashed with water and brine
  8. dry with materialIt was dried over anhydrous magnesium sulfate
  9. filtrationfiltered
  10. customevaporated

출처 및 근거

ORD 기록
ord-53767db6e48047baad2d6662a8734f6d
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699870B2

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