반응식
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].NOCCN(C)C[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2C)[C@H](O)[C@@H]1O.C(OC(=[N:36][O:37][CH2:38][CH2:39][CH2:40][CH2:41][N:42]([CH3:62])[CH2:43][C@H:44]1[O:48][C@@H:47]([N:49]2[C:58]3[C:52]([C:53]([N:55]=[CH:56][N:57]=3)=[NH:54])=[N:51][C:50]2=[O:59])[C@H:46]([OH:60])[C@@H:45]1[OH:61])C)C.OS(O)(=O)=O>>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[NH2:36][O:37][CH2:38][CH2:39][CH2:40][CH2:41][N:42]([CH3:62])[CH2:43][C@H:44]1[O:48][C@@H:47]([N:49]2[C:58]3[C:52]([C:53]([N:55]=[CH:56][N:57]=3)=[NH:54])=[N:51][C:50]2=[O:59])[C@H:46]([OH:60])[C@@H:45]1[OH:61]참가 물질
4
실험 절차
The procedure was the same as reported above for 7a using 8c (190 mg, 0.41 mmol) and 2N H2SO4 (3 mL). The compound was purified by column chromatography (elution with 4:1:0.5 chloroform:methanol:NH4OH): yield 208 mg (82%), MS: m/z 384 (M+H)+; 1HNMR (DMSO-d6) δ 10.45 (bs, 1H, 8-OH), 8.05 (s, 1H, H-2), 6.58 (bs, 2H, 6-NH2), 5.77 (d, 1H, H-1′, J1′,2′=5.0 Hz), 5.37-5.71 (bm, 2H, O—NH2), 4.83 (t, 1H, H-2′, J2′,3′=4.2 Hz), 4.18-4.29 (m, 2H, H-3′, H-4′), 3.88 (t, 2H, NH2O—CH2), 3.34-3.54 (m, 2H, 5′-CH2), 3.06 (bt, 2H, N(CH3)—CH2), 2.73 (s, 3H, N—CH3), 1.46-1.74 (bm, 4H, NH2OCH2—CH2CH2); UV λmax, nm, pH 1, 263.3 (∈ 12,200), pH 7, 268.9 (∈ 13,600), pH 13, 279.9 (∈ 15,600). Anal. (C15H25N7O5.1.9H2SO4.0.1C2H5OH.2H2O) C, H, N, S.
후처리
- customThe compound was purified by column chromatography (elution with 4:1:0.5 chloroform:methanol:NH4OH)
출처 및 근거
- ORD 기록
- ord-95f052bdcff748449e9d8a45ec2f5bf9
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637485B2
연결된 노트
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