Sodium borohydride → (2-Fluoro-4-iodopyridin-3-yl)methanol

HRID 47359

반응식

HRID 47359 반응식
[BH4-].[Na+].[F:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1>O1CCCC1>[F:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

생성물 1

HCID 11021396(2-Fluoro-4-iodopyridin-3-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.72 g (19.2 mmol) of sodium borohydride is added to a solution of 4 g (16 mmol) of 2-fluoro-4-iodo-3-pyridinecarbaldehyde (described in J.O.C., 1993, 58, pp. 7832) in 100 ml of tetrahydrofuran. The mixture is stirred at room temperature for 4 hours and then hydrolysed. The reaction mixture is extracted with ethyl acetate. The organic phases are dried and concentrated to yield the expected product.

후처리

  1. extractionThe reaction mixture is extracted with ethyl acetate
  2. customThe organic phases are dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d094e11700ea421e989ed6c166b22473
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699876B2

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